Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | HTT | P42858 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17224405 | 1.00 | MEN1 (0.55) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224293 | 0.89 | MEN1 (0.70) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224291 | 0.89 | MEN1 (0.70) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224322 | 0.80 | IDO1 (0.42) | MEN1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL18528452 | 0.80 | IDO1 (0.42) | MEN1KMT2AMAPTSMN1; SMN2TDP1 | |
| SCHEMBL17224374 | 0.74 | KDM4E (0.44) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224377 | 0.74 | KDM4E (0.44) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224279 | 0.73 | PDE4D (0.36) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL17224278 | 0.73 | PDE4D (0.36) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL1506959 | 0.73 | HTR1A (0.53) | MEN1KMT2AHTTHSP90AA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137554-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | Ecole Normale Superieure De Lyon (FR) | 2017-03-08 | — | — | EP | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| WO-2015166295-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2015-11-05 | — | — | WO | disclosed |