SCHEMBL17224804

SCHEMBL17224804

COC(=O)CC1(C)Cc2cc(C)ccc2O1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 2/20 0.41
GAA P10253 2/20 0.41
KDM4E B2RXH2 5/20 0.36
LMNA P02545 2/20 0.36
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 3/20 0.35
CA12 O43570 1/20 0.34
CA9 Q16790 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
AKR1B1 P15121 1/20 0.34
PLK1 P53350 1/20 0.33
RAD52 P43351 1/20 0.33
ATM Q13315 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17224747 0.85 AKR1B1 (0.44) GAAKDM4EALDH1A1TSHRMEN1
SCHEMBL18528473 0.80 PPARA (0.36) KDM4EALDH1A1TSHRHSD17B10HPGD
SCHEMBL25513578 0.78 IRAK4 (0.36) GAAKDM4EALDH1A1SMN1; SMN2RAD52
SCHEMBL25513496 0.76 HTR1A (0.37) USP2GAAKDM4EALDH1A1MAPT
SCHEMBL28436406 0.74 KDM4E (0.37) USP2GAAKDM4ELMNAALDH1A1
SCHEMBL19954256 0.74 SLC6A2 (0.35) USP2GAAKDM4EALDH1A1MAPT
SCHEMBL5098770 0.71 PPARA (0.44) GAAKDM4ELMNAALDH1A1MAPT
SCHEMBL28439892 0.70 DGAT1 (0.39) USP2GAAKDM4EMAPTSMN1; SMN2
SCHEMBL12856785 0.70 KDM4E (0.44) GAAKDM4EALDH1A1MAPTTSHR
SCHEMBL12035985 0.69 MAPT (0.41) GAAKDM4ELMNAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865480-B1 HYDRAZINE DERIVATIVES FMC CORP (US) 2025-11-05 EP disclosed
CN-111018790-B Pyridazinone herbicides FMC公司 2023-09-19 CN disclosed
EP-3865480-A1 HYDRAZINE DERIVATIVES FMC Corporation (US) 2021-08-18 EP disclosed
EP-3137456-B1 PYRIDAZINONE HERBICIDES FMC CORP (US) 2021-06-02 EP disclosed
CN-111018790-A Pyridazinone herbicides FMC公司 2020-04-17 CN disclosed
US-10597388-B2 Pyridazinone herbicides FMC CORPORATION (US) 2020-03-24 US disclosed
CN-106458926-B Pyridazinone herbicides FMC公司 2020-01-03 CN disclosed
US-20190016712-A1 PYRIDAZINONE HERBICIDES FMC CORPORATION 2019-01-17 US disclosed
US-10118917-B2 Pyridazinone herbicides FMC CORPORATION 2018-11-06 US disclosed
EP-3137456-A1 PYRIDAZINONE HERBICIDES E. I. du Pont de Nemours and Company (US) 2017-03-08 EP disclosed
US-20170050953-A1 PYRIDAZINONE HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2017-02-23 US disclosed
CN-106458926-A Pyridazinone herbicides 杜邦公司 2017-02-22 CN disclosed
WO-2015168010-A1 PYRIDAZINONE HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2015-11-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190016712-A1 PYRIDAZINONE HERBICIDES CBR3, NOX5, NR5A2 USP2 3601/4885GAA 3303/4885KDM4E 1868/4885
US-20170050953-A1 PYRIDAZINONE HERBICIDES CBR3, NOX5, NR5A2 USP2 3601/4885GAA 3303/4885KDM4E 1868/4885
US-10118917-B2 Pyridazinone herbicides CBR3, NOX5, NR5A2 USP2 3601/4885GAA 3303/4885KDM4E 1868/4885
US-10597388-B2 Pyridazinone herbicides CBR3, NOX5, NR5A2 USP2 3601/4885GAA 3303/4885KDM4E 1868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.