SCHEMBL172249

SCHEMBL172249

O=C1NCCCN1[C@H]1C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CDA P32320 4/20 0.58
TK1 P04183 3/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ALOX12 P18054 1/20 0.43
ADRA1A P35348 1/20 0.43
ADRB1 P08588 1/20 0.43
DNMT1 P26358 1/20 0.43
TK2 O00142 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
TSHR P16473 1/20 0.42
BLM P54132 1/20 0.42
PMP22 Q01453 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27054478 1.00 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL23240762 1.00 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL11260242 0.97 CDA (0.63) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL25824051 0.87 CDA (0.47) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL10070579 0.78 CDA (0.56) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL21423103 0.78 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL4318242 0.78 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL658757 0.78 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL15893325 0.78 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12
SCHEMBL658758 0.78 CDA (0.58) CDATK1LMNASMN1; SMN2ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230220384-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2023-07-13 US disclosed
EP-4022059-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF Wave Life Sciences Ltd. (SG) 2022-07-06 EP disclosed
CN-114585737-A Oligonucleotide compositions and methods of use thereof 波涛生命科学有限公司 2022-06-03 CN disclosed
WO-2021071858-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF WAVE LIFE SCIENCES LTD. (SG) 2021-04-15 WO disclosed
EP-2207786-B1 2'-FLUORO-2'-DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS EISAI INC (US) 2012-03-07 EP disclosed
WO-2009052287-A1 2 ' -FLU0R0-2 ' -DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS EISAL CORPORATION OF NORTH AMERICA (US) 2009-04-23 WO disclosed