Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27417114 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA4GRIK1SLC1A3 | |
| SCHEMBL15314795 | 0.78 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA4GRIK1SLC1A3 | |
| SCHEMBL25045158 | 0.76 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA4CHRNA3CHRM1 | |
| SCHEMBL11775378 | 0.76 | CHRM1 (0.42) | CHRNB2CHRNB4CHRNA4GRIK1SLC1A3 | |
| SCHEMBL6225977 | 0.75 | — | — | |
| SCHEMBL24648648 | 0.75 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA4CHRNA3CHRM1 | |
| SCHEMBL27409612 | 0.74 | CHRM1 (0.36) | CHRNB2CHRNB4CHRNA4GRIK1SLC1A3 | |
| SCHEMBL25097363 | 0.71 | CHRM1 (0.33) | CHRNB2CHRNB4CHRNA4GRIK1SLC1A3 | |
| SCHEMBL18731291 | 0.71 | CA2 (0.42) | CHRNB2CHRNB4CHRNA4TDP1CYP3A4 | |
| SCHEMBL24881082 | 0.71 | CA1 (0.38) | CHRNB2CHRNB4CHRNA4CHRNA3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272825-B1 | Protected amino hydroxy adamantane carboxylic acid and process for its preparation | ASTRAZENECA AB (SE) | 2015-11-04 | — | — | EP | disclosed |