Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTPRF | P10586 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPRA | P18433 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14645197 | 0.86 | RAF1 (0.35) | — | |
| SCHEMBL1082972 | 0.85 | NR1I2 (0.37) | NR1I2CYP2E1HCAR3ALDH1A1 | |
| SCHEMBL17226353 | 0.84 | NR1I2 (0.38) | NR1I2CYP2E1HCAR3PTPRFPTPN1 | |
| SCHEMBL15015340 | 0.78 | RAB9A (0.42) | NR1I2CYP2E1HCAR3ALDH1A1PTPN1 | |
| SCHEMBL15015299 | 0.77 | NR1I2 (0.33) | NR1I2CYP2E1 | |
| SCHEMBL16661952 | 0.77 | NR1I2 (0.41) | NR1I2CYP2E1L3MBTL1 | |
| SCHEMBL15130828 | 0.76 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL19364937 | 0.76 | NR1I2 (0.40) | NR1I2CYP2E1ALDH1A1L3MBTL1 | |
| SCHEMBL432666 | 0.75 | NR1I2 (0.39) | NR1I2CYP2E1L3MBTL1 | |
| SCHEMBL12949396 | 0.75 | NR1I2 (0.39) | NR1I2CYP2E1PTPN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403860-B1 | PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE AS HCV POLYMERASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2015-11-04 | — | — | EP | disclosed |