SCHEMBL17226503

SCHEMBL17226503

CC(C)C1CCC(CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.63
DRD3 P35462 1/20 0.63
ALDH1A1 P00352 3/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
SIGMAR1 Q99720 2/20 0.56
HTR7 P34969 5/20 0.54
NPSR1 Q6W5P4 1/20 0.54
HTR1A P08908 3/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAPT P10636 1/20 0.53
TSHR P16473 1/20 0.53
NFKB1 P19838 1/20 0.53
MAPK1 P28482 1/20 0.53
CYP2C19 P33261 1/20 0.53
THPO P40225 1/20 0.53
MTOR P42345 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3844094 0.85 DRD2 (0.67) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL17226513 0.84 DRD2 (0.63) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
Hydrochloric Acid SCHEMBL3845986 0.84 DRD2 (0.66) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
Hydrochloric Acid SCHEMBL4075439 0.84 DRD2 (0.66) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL3843635 0.82 DRD2 (0.64) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL3866800 0.82 DRD2 (0.61) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL4502702 0.82 ALDH1A1 (0.65) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL3844577 0.81 DRD2 (0.62) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL4483840 0.81 DRD2 (0.62) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL3844093 0.80 DRD2 (0.61) DRD2DRD3ALDH1A1SMN1; SMN2SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038268-B1 CARBONYLATED (AZA)CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS BIOPROJET SOC CIV (FR) 2015-11-04 EP disclosed