Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30636549 | 0.86 | TDP1 (0.55) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL16586047 | 0.86 | TDP1 (0.55) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL3208283 | 0.83 | TDP1 (0.59) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL31255154 | 0.83 | TDP1 (0.59) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL11982024 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL9290492 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL2278694 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL31255260 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL635541 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA | |
| SCHEMBL30478413 | 0.81 | TDP1 (0.58) | TDP1L3MBTL1ALDH1A1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107814759-A | The preparation method of fluopicolide | 常州沃腾化工科技有限公司 | 2018-03-20 | — | — | CN | claimed |
| CN-107216284-A | The preparation method of the trifluoromethyl pyridine hydrochloride of 2 aminomethyl, 3 chlorine 5 | 杨子辉 | 2017-09-29 | — | — | CN | claimed |
| CN-119143663-A | Method for preparing 2-aminomethyl-3-chloro-5-trifluoromethyl pyridine hydrochloride | 阜新都创新材料科技有限公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-115784976-A | Improved preparation method of fluopicolide | 武威广达科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| EP-3495360-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-06-12 | — | — | EP | disclosed |
| US-9926302-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-03-27 | — | — | US | disclosed |
| US-9926302-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-03-27 | — | — | US | disclosed |
| CN-107814759-A | The preparation method of fluopicolide | 常州沃腾化工科技有限公司 | 2018-03-20 | — | — | CN | disclosed |
| US-9879000-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-01-30 | — | — | US | disclosed |
| US-9879000-B2 | Heteroaryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-01-30 | — | — | US | disclosed |
| CN-107216284-A | The preparation method of the trifluoromethyl pyridine hydrochloride of 2 aminomethyl, 3 chlorine 5 | 杨子辉 | 2017-09-29 | — | — | CN | disclosed |
| WO-2015158427-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015158427-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| US-20150291572-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291572-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| EP-2344450-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20110172236-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CHAKRAVARTY PRASUN K | 2011-07-14 | — | — | US | disclosed |
| WO-2010036589-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK SHARP & DOHME CORP. (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-1987024-A1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | Istituto di Ricerche di Biologia Molecolare P. Angeletti (IT) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093827-A1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291572-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | TRPV1, CACNA1B, CACNA1C | TDP1 3563/4885L3MBTL1 4132/4885ALDH1A1 2565/4885 |
| US-20110172236-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TRPV1, TRPA1, CACNA1D | TDP1 3914/4885L3MBTL1 4377/4885ALDH1A1 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.