Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 10/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CD74 | P04233 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11579267 | 0.78 | NPC1 (0.66) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171364 | 0.76 | NPC1 (0.73) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL4395868 | 0.76 | NPC1 (0.72) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12482950 | 0.76 | KDM4E (0.45) | KMT2AALDH1A1HPGDMAPK1MEN1 | |
| SCHEMBL18708511 | 0.74 | MYC (0.50) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10483674 | 0.73 | MYC (0.67) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171944 | 0.72 | ALDH1A1 (0.56) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171784 | 0.72 | NPC1 (0.62) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171743 | 0.72 | NPC1 (0.74) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12798166 | 0.72 | NPC1 (0.62) | MYCNPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3067053-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2016-09-14 | — | — | EP | disclosed |
| EP-2939674-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2015-11-04 | — | — | EP | disclosed |