Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CD74 | P04233 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11579267 | 0.80 | NPC1 (0.66) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171364 | 0.78 | NPC1 (0.73) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL4395868 | 0.77 | NPC1 (0.72) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL18708458 | 0.77 | MYC (0.51) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10483674 | 0.75 | MYC (0.67) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171984 | 0.75 | NPC1 (0.59) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL17226775 | 0.74 | MYC (0.48) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL29906797 | 0.74 | KDM4E (0.60) | KMT2ASMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL3096217 | 0.74 | KDM4E (0.60) | KMT2ASMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL12171944 | 0.74 | ALDH1A1 (0.56) | MYCNPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |