Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | OGG1 | O15527 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518614 | 0.83 | NOS1 (0.46) | MAPTGFERKDM4EALDH1A1NPC1 | |
| SCHEMBL518402 | 0.77 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL13259398 | 0.77 | MAPT (0.53) | MAPTGFERCYP3A4HIF1AKDM4E | |
| SCHEMBL519184 | 0.75 | SMN1; SMN2 (0.55) | MAPTCYP3A4KDM4EALDH1A1NPC1 | |
| SCHEMBL11860787 | 0.75 | MAPT (0.56) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL518754 | 0.75 | ALDH1A1 (0.51) | MAPTGFERKDM4EALDH1A1NPC1 | |
| SCHEMBL518727 | 0.75 | MEN1 (0.52) | MAPTGFERALDH1A1NPC1RAB9A | |
| SCHEMBL8369509 | 0.75 | MAPT (0.42) | MAPTGFERKDM4EALDH1A1NPC1 | |
| SCHEMBL518630 | 0.75 | EPHX2 (0.50) | MAPTALDH1A1NPC1RAB9AGAA | |
| SCHEMBL18793258 | 0.75 | MAPT (0.45) | MAPTGFERCYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393360-B1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |