Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GHSR | Q92847 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441294 | 0.89 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTGHSRGFERCHRM2 | |
| SCHEMBL2445002 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTGHSRCYP3A4GFER | |
| SCHEMBL12328016 | 0.86 | GHSR (0.59) | SMN1; SMN2MAPTGHSRCYP3A4GFER | |
| SCHEMBL12299405 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTGHSRGFERCHRM2 | |
| SCHEMBL17227462 | 0.82 | GHSR (0.61) | GHSRCYP3A4CYP2C19CYP2C9CHRM2 | |
| Hydrochloric Acid SCHEMBL2431655 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTGHSRGFERCHRM2 | |
| SCHEMBL2236750 | 0.77 | SMN1; SMN2 (0.84) | SMN1; SMN2MAPTGFERL3MBTL1HPGD | |
| SCHEMBL9321597 | 0.76 | MAPT (1.00) | SMN1; SMN2MAPTGFERL3MBTL1HPGD | |
| SCHEMBL92507 | 0.76 | SMN1; SMN2 (0.82) | SMN1; SMN2MAPTGFERL3MBTL1HPGD | |
| SCHEMBL26099620 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTCYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547679-B1 | 2,3 DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.6]NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR | PFIZER (US) | 2015-11-04 | — | — | EP | disclosed |