Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | GFER | P55789 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975592 | 0.92 | MAPT (0.84) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL3673014 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTGFERL3MBTL1HPGD | |
| SCHEMBL2236750 | 0.86 | SMN1; SMN2 (0.84) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL9321597 | 0.84 | MAPT (1.00) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL13068565 | 0.84 | FKBP1A (0.60) | SMN1; SMN2MAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL31499418 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL31499420 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL31499419 | 0.83 | SMN1; SMN2 (0.79) | SMN1; SMN2MAPTHSD17B10GFERL3MBTL1 | |
| SCHEMBL654109 | 0.83 | TPSAB1 (0.76) | SMN1; SMN2MAPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL27253358 | 0.82 | MEN1 (0.65) | SMN1; SMN2GFERHPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065882-A1 | VLA-4 inhibitory drug | MACHINAGA NOBUO (JP) | 2013-03-14 | — | — | US | disclosed |
| US-8129366-B2 | VLA-4 inhibitory drug | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065882-A1 | VLA-4 inhibitory drug | VCAM1, ITGB4, ITGA4 | SMN1; SMN2 4702/4885MAPT 4773/4885HSD17B10 861/4885 |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | SMN1; SMN2 4787/4885MAPT 4795/4885HSD17B10 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.