Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14390861 | 0.78 | RAF1 (0.43) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL2729001 | 0.78 | GSK3B (0.43) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL21152318 | 0.76 | IKBKB (0.42) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL13545972 | 0.76 | RAF1 (0.39) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL161941 | 0.74 | L3MBTL1 (0.60) | RAF1MAPTL3MBTL1PKM | |
| SCHEMBL1979077 | 0.73 | RAF1 (0.51) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL12523234 | 0.73 | RAF1 (0.51) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL24212419 | 0.73 | L3MBTL1 (0.46) | RAF1MAPTKMT2ATSHRHSD17B10 | |
| SCHEMBL13545968 | 0.72 | ALDH1A1 (0.40) | RAF1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL12272546 | 0.71 | RAF1 (0.52) | RAF1ALDH1A1MAPTKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611790-B1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT INC (US) | 2015-11-04 | — | — | EP | disclosed |