Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19195119 | 0.83 | HCRTR2 (0.41) | TERTHCRTR2FFAR1HTR1AHTR1D | |
| SCHEMBL19199575 | 0.76 | HCRTR2 (0.44) | TERTHCRTR2FFAR1HTR1AHTR1D | |
| SCHEMBL19194689 | 0.74 | HCRTR2 (0.42) | TERTHCRTR2FFAR1HTR1AHTR1D | |
| SCHEMBL758865 | 0.69 | PNMT (0.47) | TERTHCRTR2HTR2CPNMTCHRNB2 | |
| SCHEMBL760504 | 0.67 | HCRTR2 (0.39) | TERTHCRTR2HTR2CPNMTCYP1A2 | |
| SCHEMBL17107572 | 0.66 | PNMT (0.45) | TERTHCRTR2FFAR1HTR2CPNMT | |
| SCHEMBL31136214 | 0.66 | HCRTR2 (0.44) | TERTHCRTR2HTR2CPNMTCYP1A2 | |
| SCHEMBL21810954 | 0.65 | HCRTR2 (0.43) | TERTHCRTR2FFAR1PNMTCHRNB2 | |
| SCHEMBL18963298 | 0.62 | HCRTR2 (0.41) | TERTHCRTR2FFAR1PNMTCYP1A2 | |
| SCHEMBL17123768 | 0.62 | HCRTR2 (0.41) | TERTHCRTR2FFAR1PNMTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403835-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2012-01-11 | — | — | EP | disclosed |