Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30230052 | 1.00 | TSHR (0.67) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL186825 | 1.00 | TSHR (0.67) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21689895 | 1.00 | TSHR (0.67) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30229974 | 1.00 | TSHR (0.67) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9608966 | 1.00 | TSHR (0.67) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL16992064 | 0.98 | TSHR (0.70) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL29897763 | 0.98 | TSHR (0.70) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL19583552 | 0.98 | TSHR (0.70) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL19584295 | 0.90 | TSHR (0.56) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27632988 | 0.86 | TSHR (0.50) | TSHRNPSR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111718290-A | Synthesis method of multi-configuration isoindoline-1-carboxylic acid amino acid compound | 苏州爱玛特生物科技有限公司 | 2020-09-29 | — | — | CN | claimed |
| CN-101812010-A | Isoindolinylcarboxylic ester derivative and preparation method | UNIV TIANJIN | 2010-08-25 | — | — | CN | claimed |
| EP-3253752-B1 | [9,10-DIMETHOXY-3-(2-METHYLPROPYL)-1H,2H,3H,4H,6H,7H,11BH-PYRIDO-[2,1-A]ISOQUINOLIN-2-YL]METHANOL AND COMPOUNDS, COMPOSITIONS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230242512-A1 | ISOINDOLINES AS HDAC INHIBITORS | VALO HEALTH, INC. | 2023-08-03 | — | — | US | disclosed |
| US-20230233560-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230233560-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230212788-A1 | NEW METHOD FOR AUTOMATED ON-DEMAND BIOMOLECULAR ARRAY SYNTHESIS | Technische Universität Dresden (DE) | 2023-07-06 | — | — | US | disclosed |
| CN-115857219-A | Display device | 广州华星光电半导体显示技术有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4127718-A1 | NEW METHOD FOR AUTOMATED ON-DEMAND BIOMOLECULAR ARRAY SYNTHESIS | Technische Universität Dresden (DE) | 2023-02-08 | — | — | EP | disclosed |
| US-11535607-B2 | Isoindolines as HDAC inhibitors | VALO HEALTH, INC. (US) | 2022-12-27 | — | — | US | disclosed |
| CN-109071525-B | Dimeric compounds | 豪夫迈·罗氏有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-101812010-A | Isoindolinylcarboxylic ester derivative and preparation method | UNIV TIANJIN | 2010-08-25 | — | — | CN | disclosed |
| CN-101801918-A | Monoamide derivatives as orexin receptor antagonists | HOFFMANN LA ROCHE | 2010-08-11 | — | — | CN | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| CN-101304989-A | Carbocyclic fused cyclic amines as inhibitors of the coagulation factor XA | HOFFMANN LA ROCHE (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-101094833-A | Tetrapeptide analogs | IDUN PHARMACEUTICALS INC (US) | 2007-12-26 | — | — | CN | disclosed |
| US-20070112012-A1 | Carbocyclic fused cyclic amines | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-17 | — | — | US | disclosed |
| US-20060160840-A1 | N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; thrombosis; inhibits coagulation of a blood sample | PORTOLA PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | US | disclosed |
| EP-0093805-B1 | OCTAHYDRO-2-(OMEGA-MERCAPTOALKANOYL)3-OXO-1H-ISOINDOLE-1-CARBOXYLIC ACIDS AND ESTERS | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4503043-A | HYPOTENSIVES | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112012-A1 | Carbocyclic fused cyclic amines | F12, F11, F2 | TSHR 668/4885NPSR1 155/4885SLC6A2 3176/4885 |
| US-11535607-B2 | Isoindolines as HDAC inhibitors | HDAC1, HDAC2, HDAC3 | TSHR 2912/4885NPSR1 2275/4885SLC6A2 3114/4885 |
| US-20230242512-A1 | ISOINDOLINES AS HDAC INHIBITORS | HDAC1, HDAC2, HDAC3 | TSHR 3102/4885NPSR1 2469/4885SLC6A2 3199/4885 |
| US-20060160840-A1 | N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2N-(4-chlorophenylaminocarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; thrombosis; inhibits coagulation of a blood sample | TFPI, F2, TFPI2 | TSHR 3487/4885NPSR1 1564/4885SLC6A2 1946/4885 |
| US-20230233560-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1B, SLC26A4 | TSHR 1187/4885NPSR1 796/4885SLC6A2 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.