Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 19/20 | 0.52 |
| ▸ | GSTM2 | P28161 | 19/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959168 | 0.91 | GSTP1 (0.64) | GSTP1GSTM2IDO1 | |
| SCHEMBL26425058 | 0.78 | GSTP1 (0.64) | GSTP1GSTM2 | |
| SCHEMBL26424956 | 0.69 | GSTP1 (0.42) | GSTP1GSTM2 | |
| SCHEMBL26797780 | 0.69 | GSTP1 (0.57) | GSTP1GSTM2 | |
| SCHEMBL26424984 | 0.69 | IDO1 (0.58) | GSTP1GSTM2IDO1 | |
| SCHEMBL26424615 | 0.68 | GSTP1 (0.55) | GSTP1GSTM2IDO1 | |
| SCHEMBL6056044 | 0.61 | GSTP1 (1.00) | GSTP1GSTM2 | |
| SCHEMBL2831218 | 0.60 | ALDH1A1 (0.50) | — | |
| SCHEMBL3306592 | 0.60 | NPC1 (0.49) | — | |
| SCHEMBL3026131 | 0.60 | KMT2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | GSTP1 2223/4885GSTM2 1851/4885IDO1 3419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.