Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24045549 | 0.87 | HSD17B10 (0.39) | HSD17B10ALPLTSHRCYP2C19ALDH1A1 | |
| SCHEMBL16127913 | 0.78 | CYP2C19 (0.33) | CYP2C19 | |
| SCHEMBL21334031 | 0.77 | CYP2C19 (0.32) | CYP2C19 | |
| SCHEMBL17229819 | 0.74 | CYP2C19 (0.37) | CYP2C19 | |
| SCHEMBL19153171 | 0.70 | HSD17B10 (0.41) | HSD17B10ALPLTSHRALDH1A1 | |
| SCHEMBL17232733 | 0.68 | CYP2C19 (0.33) | CYP2C19 | |
| SCHEMBL20952906 | 0.68 | CYP2C19 (0.51) | HSD17B10CYP2C19 | |
| SCHEMBL17234775 | 0.68 | HSD17B10 (0.36) | HSD17B10TSHR | |
| SCHEMBL20695713 | 0.67 | HSD17B10 (0.34) | HSD17B10TSHR | |
| SCHEMBL23642318 | 0.67 | HSD17B10 (0.41) | HSD17B10ALPLTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913746-B2 | Substituted 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-02-09 | — | — | US | disclosed |
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-09-29 | — | — | US | disclosed |
| WO-2015168286-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARAITON AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913746-B2 | Substituted 4-phenylpiperidines, their preparation and use | HRH4, HRH3, HRH2 | HSD17B10 3146/4885ALPL 4876/4885TSHR 110/4885 |
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | QDPR, DPYD, DHPS | HSD17B10 2984/4885ALPL 2898/4885TSHR 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.