⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428144 | 0.76 | — | — | |
| SCHEMBL571056 | 0.76 | RIPK1 (0.35) | — | |
| SCHEMBL2498160 | 0.75 | RIPK1 (0.31) | — | |
| SCHEMBL4190582 | 0.70 | — | — | |
| SCHEMBL4842476 | 0.70 | — | — | |
| SCHEMBL2255605 | 0.70 | — | — | |
| SCHEMBL1748644 | 0.70 | — | — | |
| SCHEMBL9732534 | 0.70 | — | — | |
| SCHEMBL9732543 | 0.70 | — | — | |
| SCHEMBL8171559 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320198-A1 | SALT OF ENDOTHELIN A (ETA) RECEPTOR ANTAGONIST COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD (CN) | 2025-10-16 | — | — | US | disclosed |
| EP-4545520-A1 | SALT OF ENDOTHELIN A (ETA) RECEPTOR ANTAGONIST COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Shenzhen Salubris Pharmaceuticals Co., Ltd (CN) | 2025-04-30 | — | — | EP | disclosed |
| CN-119487020-A | Salt of endothelin A (ETA) receptor antagonist compound, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2025-02-18 | — | — | CN | disclosed |
| WO-2025001408-A1 | PHOSPHORUS-CONTAINING OR SULFUR-CONTAINING MACROCYCLIC PYRAZOLOPYRIMIDINE COMPOUND AND USE THEREOF | 浙江养生堂天然药物研究所有限公司 | 2025-01-02 | — | — | WO | disclosed |
| CN-118772120-A | Endothelin A (ETA) receptor antagonist compound and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-118574832-A | Tri-fused ring compound, preparation, pharmaceutical composition and application thereof | 上海奕拓医药科技有限责任公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-116194449-B | Endothelin A (ETA) receptor antagonist compound and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118304295-A | Pharmaceutical composition of endothelin A (ETA) receptor antagonist compound and application thereof | 深圳信立泰药业股份有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2024022262-A1 | SALT OF ENDOTHELIN A (ETA) RECEPTOR ANTAGONIST COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2024-02-01 | — | — | WO | disclosed |
| CN-117447453-A | Pharmaceutically acceptable salt crystal forms of endothelin A (ETA) receptor antagonist compounds and preparation method thereof | 深圳信立泰药业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-20030022881-A1 | Novel carbapenem derivatives of quarternary salt type | MEIJI SEIKA KAISHA, LTD. (JP) | 2003-01-30 | — | — | US | disclosed |
| EP-1251133-A1 | NOVEL CARBAPENEM DERIVATIVES | MEIJI SEIKA KAISHA LTD. (JP) | 2002-10-23 | — | — | EP | disclosed |
| EP-1251134-A1 | NOVEL CARBAPENEM DERIVATIVES OF QUATERNARY SALT TYPE | MEIJI SEIKA KAISHA LTD. (JP) | 2002-10-23 | — | — | EP | disclosed |
| EP-0656348-B1 | Aceric acid derivatives as medicaments | HOFFMANN LA ROCHE (CH) | 2000-05-03 | — | — | EP | disclosed |
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |
| US-5726185-A | BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELET AGGREGATION AND CELL TO CELL ADHESION | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0722447-A1 | 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-24 | — | — | EP | disclosed |
| EP-0656348-A2 | Aceric acid derivatives as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-07 | — | — | EP | disclosed |
| WO-1995010520-A1 | 3-PYRROLIDINYLTHIO-CARBAPENEM DERIVATIVES AND THEIR ANTIMICROBAL ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-20 | — | — | WO | disclosed |
| WO-1993017034-A1 | AMPHOTERICIN B DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1993-09-02 | — | — | WO | disclosed |