Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17238739 | 0.82 | CYP11B1 (0.46) | PLK1CYP11B1CYP11B2CYP17A1CYP1A2 | |
| SCHEMBL17247300 | 0.78 | CYP11B1 (0.45) | CYP11B1CYP11B2CYP17A1CYP1A2CYP19A1 | |
| SCHEMBL15839038 | 0.77 | CYP11B2 (0.46) | CYP11B1CYP11B2CYP17A1CYP1A2CYP19A1 | |
| SCHEMBL17238736 | 0.74 | CYP11B1 (0.49) | CYP11B1CYP11B2CYP19A1CYP2C9LMNA | |
| SCHEMBL29591487 | 0.72 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP17A1CYP1A2CYP19A1 | |
| SCHEMBL13202647 | 0.72 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP17A1CYP1A2CYP19A1 | |
| SCHEMBL15839074 | 0.70 | CYP11B2 (0.62) | PLK1CYP11B1CYP11B2CYP19A1CYP2C9 | |
| SCHEMBL12253506 | 0.69 | CA9 (0.53) | PLK1CYP11B1CYP11B2LMNAL3MBTL1 | |
| SCHEMBL26100088 | 0.69 | CYP17A1 (0.42) | CYP11B2CYP17A1CYP1A2CA12CA1 | |
| SCHEMBL13202375 | 0.68 | PLK1 (0.50) | PLK1CYP11B1CYP11B2CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934144-B1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-2934144-B1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-07-19 | — | — | EP | disclosed |
| US-9522141-B2 | Indazole compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522141-B2 | Indazole compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-12-20 | — | — | US | disclosed |
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | disclosed |
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150320733-A1 | INDAZOLE COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | HSD11B1, CYP21A2, CYP11B1 | PLK1 1303/4885CYP11B1 3/4885CYP11B2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.