Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877136 | 0.91 | ROCK2 (0.48) | ROCK2ABCG2PRKD3METROCK1 | |
| SCHEMBL14202082 | 0.90 | ROCK2 (0.52) | ROCK2ABCG2PRKD3METROCK1 | |
| SCHEMBL4780066 | 0.88 | MEN1 (0.53) | ROCK2ABCG2MEN1KMT2AMAPT | |
| SCHEMBL4780078 | 0.88 | MEN1 (0.53) | ROCK2ABCG2MEN1KMT2AMAPT | |
| SCHEMBL877621 | 0.88 | ROCK2 (0.45) | ROCK2ABCG2 | |
| SCHEMBL877856 | 0.87 | ROCK2 (0.68) | ROCK2ABCG2ROCK1CSNK2A1STK3 | |
| SCHEMBL4782453 | 0.85 | ABCG2 (0.53) | ROCK2ABCG2ROCK1MEN1KMT2A | |
| SCHEMBL1729989 | 0.85 | ABCG2 (0.60) | ROCK2ABCG2PRKD3METROCK1 | |
| SCHEMBL1729984 | 0.84 | ROCK2 (0.46) | ROCK2ABCG2PRKD3METCLK4 | |
| SCHEMBL876780 | 0.80 | MEN1 (0.49) | ROCK2ABCG2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |