Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1415171 | 0.94 | ALDH1A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3580804 | 0.93 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3600047 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3594756 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3598527 | 0.79 | PDE4B (0.42) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL5327111 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL30641473 | 0.79 | ALDH1A1 (0.71) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL2990370 | 0.78 | TUBB4A (0.49) | ALDH1A1KDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL3580803 | 0.78 | PDE4B (0.42) | ALDH1A1KDM4ESMN1; SMN2MAPTTHRB | |
| SCHEMBL1415794 | 0.73 | S1PR1 (0.42) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656373-B1 | DERIVATIVES OF 2-ACYLAMINO-4-PHENYLTHIAZOLE, PREPARATION METHOD THEREOF AND USE OF SAME AS CHEMOKINEANTAGONISTS | SANOFI SA (FR) | 2012-01-18 | — | — | EP | disclosed |
| EP-1656373-A2 | DERIVATIVES OF 2-ACYLAMINO-4-PHENYLTHIAZOLE, PREPARATION METHOD THEREOF AND USE OF SAME AS CHEMOKINEANTAGONISTS | Sanofi-Aventis (FR) | 2006-05-17 | — | — | EP | disclosed |
| WO-2004096798-A2 | DERIVATIVES OF 2-ACYLAMINO-4-PHENYLTHIAZOLE, PREPARATION METHOD THEREOF AND USE OF SAME AS CHEMOKINE ANTAGONISTS | SANOFI-AVENTIS (FR) | 2004-11-11 | — | — | WO | disclosed |