Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | AGER | Q15109 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PER2 | O15055 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027770 | 0.88 | SMN1; SMN2 (0.53) | PARP1DAOPARP2ALDH1A1KDM4E | |
| SCHEMBL30704833 | 0.88 | SMN1; SMN2 (0.53) | PARP1DAOPARP2ALDH1A1KDM4E | |
| SCHEMBL6300121 | 0.85 | PARP1 (0.46) | PARP1DAOPARP2ALDH1A1 | |
| SCHEMBL10834234 | 0.81 | MEN1 (0.63) | DAOIDO1ALDH1A1 | |
| SCHEMBL6027805 | 0.79 | CYP1A2 (0.64) | PARP1DAOALDH1A1KDM4E | |
| SCHEMBL30145436 | 0.78 | BACE1 (0.70) | BACE1AGERALDH1A1KDM4EPER2 | |
| SCHEMBL11788371 | 0.78 | BACE1 (0.70) | BACE1AGERALDH1A1KDM4EPER2 | |
| SCHEMBL6800624 | 0.78 | DAO (0.43) | PARP1BACE1DAOIDO1 | |
| SCHEMBL11983439 | 0.77 | PARP1 (0.56) | PARP1DAOPARP2KDM4E | |
| SCHEMBL6295245 | 0.77 | PARP1 (0.53) | PARP1DAOPARP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140301-A1 | PHARMACOLOGICALLY ACTIVE QUINAZOLINEDIONE DERIVATIVES | Orion Corporation (FI) | 2017-03-15 | — | — | EP | claimed |
| WO-2015169999-A1 | PHARMACOLOGICALLY ACTIVE QUINAZOLINEDIONE DERIVATIVES | ORION CORPORATION (FI) | 2015-11-12 | — | — | WO | claimed |