Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30704833 | 0.88 | SMN1; SMN2 (0.53) | PARP1DAOCYP1A2PARP2ALDH1A1 | |
| SCHEMBL6027770 | 0.88 | SMN1; SMN2 (0.53) | PARP1DAOCYP1A2PARP2ALDH1A1 | |
| SCHEMBL6295245 | 0.85 | PARP1 (0.53) | PARP1DAOMEN1CYP1A2KMT2A | |
| SCHEMBL17242599 | 0.85 | PARP1 (0.49) | PARP1DAOPARP2ALDH1A1 | |
| SCHEMBL6800624 | 0.84 | DAO (0.43) | PARP1DAOMEN1CYP1A2KMT2A | |
| SCHEMBL6027805 | 0.79 | CYP1A2 (0.64) | PARP1DAOMEN1CYP1A2KMT2A | |
| SCHEMBL6294349 | 0.76 | PARP1 (0.52) | PARP1DAOCYP1A2ALDH1A1TSHR | |
| SCHEMBL6294025 | 0.76 | PARP1 (0.46) | PARP1DAOMEN1CYP1A2KMT2A | |
| SCHEMBL6804934 | 0.76 | CYP1A2 (0.65) | MEN1CYP1A2KMT2AALDH1A1TSHR | |
| SCHEMBL6794703 | 0.75 | PARP1 (0.46) | PARP1DAOPARP2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |
| EP-1150964-B1 | POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS | IBFB GMBH PRIVATES INST FUER B (DE) | 2003-10-29 | — | — | EP | disclosed |
| EP-1150964-A2 | POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001014344-A2 | POLYCYCLIC PYRIMIDINE-2,4(1H, 3H)-DIONE WITH FUNCTIONALIZED ALKYL RADICALS IN 1- AND/OR 3-POSITION, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS | IBFB GMBH PRIVATES INSTITUT FÜR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2001-03-01 | — | — | WO | disclosed |