Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8105641 | 0.82 | CYP3A4 (0.49) | ACKR3CYP3A4CYP3A5 | |
| SCHEMBL211238 | 0.78 | CYP3A4 (0.52) | CYP3A4CYP3A5 | |
| SCHEMBL30340993 | 0.76 | KCNA5 (0.55) | CYP3A4CYP3A5KDM4E | |
| SCHEMBL8863358 | 0.76 | CYP11B1 (0.46) | CYP3A4CYP3A5CYP19A1 | |
| SCHEMBL16026426 | 0.74 | KCNA5 (0.53) | KDM4E | |
| SCHEMBL30233132 | 0.74 | KCNA5 (0.53) | KDM4E | |
| SCHEMBL8146861 | 0.73 | SLC1A2 (0.47) | — | |
| SCHEMBL2732264 | 0.72 | CYP2D6 (0.45) | CYP3A4CYP3A5KDM4E | |
| SCHEMBL18263808 | 0.72 | LTA4H (0.62) | ACKR3 | |
| SCHEMBL210120 | 0.72 | CYP3A4 (0.61) | CYP3A4CYP3A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1700856-B1 | THIAZOLE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |