⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16051027 | 0.98 | — | — | |
| SCHEMBL2823555 | 0.79 | — | — | |
| SCHEMBL2281780 | 0.76 | — | — | |
| SCHEMBL14654544 | 0.75 | — | — | |
| SCHEMBL11651813 | 0.74 | — | — | |
| SCHEMBL14996956 | 0.72 | — | — | |
| SCHEMBL1383836 | 0.71 | EPAS1 (0.30) | — | |
| SCHEMBL2307623 | 0.69 | — | — | |
| SCHEMBL11721451 | 0.69 | CHRNB2 (0.30) | — | |
| SCHEMBL11215030 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729274-B2 | Tricyclic heterocyclic derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-05-20 | — | — | US | disclosed |
| US-20120232122-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-09-13 | — | — | US | disclosed |
| EP-2406217-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | MSD Oss B.V. (NL) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103001-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2010-09-16 | — | — | WO | disclosed |
| EP-1000621-A2 | Use of 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz (CD) indoles for treating motion sickness and vomiting | ELI LILLY AND COMPANY (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0506363-B1 | 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0506369-B1 | 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles | LILLY CO ELI (US) | 1998-07-22 | — | — | EP | disclosed |
| US-5783590-A | ADJUSTMENT OF SEROTONIN CONCENTRATION IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-07-21 | — | — | US | disclosed |
| US-5750554-A | COMPOUNDS FOR TREATMENT OF ANXIETY, DEPRESSION, ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS AND TREATMENT OF EATING PROBLEMS | ELI LILLY AND COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5736562-A | MODIFY FUNCTION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5624944-A | SEROTONIN RELATED ILLNESS SUCH AS ANXIETY, DEPRESSION, ANTISECRETORY AGENTS FOR GASTRIC JUICE AND DEMENTIA | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-5594019-A | SEROTONIN DISORDERS | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5364856-A | Modification of serotonin function | ELI LILLY AND COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| US-5347013-A | FOR TREATING MAMMALS WITH SEROTONIN RELATED DISORDERS | ELI LILLY AND COMPANY (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0590970-A1 | 6-Heterocyclyl-4-amino-1,2,2a,3,4,5-hexahydrobenz CD indoles for treating motion sickness and vomiting | ELI LILLY AND COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0590971-A1 | 6-Heterocyclyl-4-amino-1,3,4,5-tetrahydrobenz CD indoles for treating motion sickness and vomiting | ELI LILLY AND COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5244912-A | Serotonin antagonist | ELI LILLY AND COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5244911-A | Serotonin antagonist | ELI LILLY AND COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0506363-A1 | 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |
| EP-0506369-A1 | 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |