Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429295 | 0.76 | MAPT (0.43) | DHFRADORA2ASYKMAPTSMN1; SMN2 | |
| SCHEMBL5199692 | 0.69 | MAPT (0.51) | MAPTSMN1; SMN2KMT2ADYRK1APDE3B | |
| SCHEMBL6700778 | 0.67 | KMT2A (0.54) | DHFRADORA2AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2425567 | 0.66 | NPC1 (0.53) | ADORA2ASYKMAPTCYP1A2KMT2A | |
| SCHEMBL12076878 | 0.65 | CYP1A1 (0.56) | ADORA2AMAPTSMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL11087367 | 0.65 | APOBEC3A (0.47) | APOBEC3AAPOBEC3GMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL21852751 | 0.64 | ALDH1A1 (0.67) | ADORA2AMAPTKMT2AADORA1CA1 | |
| SCHEMBL11086899 | 0.64 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL1622459 | 0.64 | KDM4E (0.54) | MAPTSMN1; SMN2CYP1A2KMT2ADYRK1A | |
| SCHEMBL4124300 | 0.64 | ENPP1 (0.66) | KMT2ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542239-B1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | Université Joseph Fourier (FR) | 2015-11-11 | — | — | EP | disclosed |