Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 9/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123166 | 0.84 | MTNR1B (0.54) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL123165 | 0.84 | MTNR1B (0.54) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL126190 | 0.70 | MTNR1B (0.53) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL12424531 | 0.70 | MTNR1A (0.48) | MTNR1BMTNR1A | |
| SCHEMBL124619 | 0.67 | MTNR1B (0.69) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL2881136 | 0.63 | MTNR1B (0.56) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL793401 | 0.63 | MTNR1B (0.56) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL805922 | 0.63 | MTNR1B (0.56) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL124497 | 0.61 | MTNR1B (0.44) | MTNR1BMTNR1AABCB11SIGMAR1USP2 | |
| SCHEMBL124498 | 0.61 | MTNR1B (0.44) | MTNR1BMTNR1AABCB11SIGMAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |
| EP-2100895-A1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-09-16 | — | — | EP | disclosed |