SCHEMBL172459

SCHEMBL172459

N#Cc1cnn2c(O)ccnc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.60
ALDH1A1 P00352 6/20 0.60
HPGD P15428 3/20 0.60
CLK4 Q9HAZ1 1/20 0.60
KDM4D Q6B0I6 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.54
CDK2 P24941 1/20 0.49
MDM2 Q00987 1/20 0.45
POLB P06746 2/20 0.44
LMNA P02545 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
MAPK1 P28482 2/20 0.44
GABRA1 P14867 1/20 0.44
GABRG2 P18507 1/20 0.44
GABRB3 P28472 1/20 0.44
GABRA2 P47869 1/20 0.44
GABRB2 P47870 1/20 0.44
AOX1 Q06278 1/20 0.44
PDE3A Q14432 1/20 0.44
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26621936 0.81 KDM4E (0.59) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL29071790 0.80 KDM4E (0.74) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL24938786 0.77 KDM4E (0.36) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL11346886 0.76 KDM4E (0.78) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL9468787 0.76 KDM4E (1.00) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL127121 0.74 SMPD3 (0.43) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL19201115 0.74 KDR (0.44) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL13153941 0.74 KDM4E (0.56) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL9468406 0.73 KDM4E (0.74) KDM4EALDH1A1HPGDCLK4KDM4D
SCHEMBL29355477 0.73 KDM4E (0.62) KDM4EALDH1A1HPGDCLK4KDM4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054021-B1 HAIR DYE COMPRISING RICE GERM OIL AND PROTEIN HYDROLYZATE HENKEL AG & CO KGAA (DE) 2017-10-18 EP disclosed
EP-1978840-B1 AUXILIARY AGENT FOR STYLISHLY COLOURING KERATIN-CONTAINING FIBRES HENKEL AG & CO KGAA (DE) 2016-07-06 EP disclosed
EP-2026754-B1 LIGHTENING AND/OR COLOURING AGENT COMPRISING CYCLIC UREA DERIVATIVES HENKEL AG & CO KGAA (DE) 2015-09-30 EP disclosed
EP-1432395-B1 METHOD FOR COLOURING KERATIN FIBRES USING CARBONYL COMPOUNDS TO IMPROVE THE COLOUR STABILITY OF HAIR COLORATION HENKEL AG & CO KGAA (DE) 2012-08-08 EP disclosed
EP-1962776-B1 HAIR BLEACHING COMPOSITION HENKEL AG & CO KGAA (DE) 2012-08-08 EP disclosed
EP-1778363-B1 STABLE GEL-FORMULATION WITH INCREASED ELECTROLYTE CONCENTRATION HENKEL AG & CO KGAA (DE) 2012-08-01 EP disclosed
EP-1778176-B1 COMPOSITION FOR COLOURING KERATIN-CONTAINING FIBRES HENKEL AG & CO KGAA (DE) 2012-07-25 EP disclosed
EP-1669108-B1 Odour-reducing hair treatment and composition HENKEL AG & CO KGAA (DE) 2012-03-07 EP disclosed
WO-2011141069-A2 PROCESS FOR PREPARING A COLOURING COMPOSITION FOR KERATIN FIBRES HENKEL AG & CO. KGAA (DE) 2011-11-17 WO disclosed
EP-1986590-B1 RHEOPEXY GELS AS VEHICLES HENKEL AG & CO KGAA (DE) 2011-11-16 EP disclosed
EP-1292272-B1 OXIDATION DYE FOR HAIR HENKEL KGAA (DE) 2007-03-07 EP disclosed
EP-1531853-B1 SYNERGISTIC COMBINATION OF SILK PROTEINS HENKEL KGAA (DE) 2007-02-28 EP disclosed
WO-2007019930-A1 AGENT FOR DYEING KERATINOUS FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-02-22 WO disclosed
WO-2007019931-A1 AGENT FOR DYEING KERATINOUS FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-02-22 WO disclosed
EP-1754515-A1 Hair dyeing and treatment kit containing dyes and colour protecting agents Henkel Kommanditgesellschaft auf Aktien (DE) 2007-02-21 EP disclosed
WO-2007017048-A1 METHOD FOR QUICKLY CONCEALING THE ROOTS OF HAIR THAT HAVE GROWN AFTER THE HAIR HAS BEEN DYED HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-02-15 WO disclosed
EP-1752138-A2 Amaranth seed oil in hair compositions Henkel Kommanditgesellschaft auf Aktien (DE) 2007-02-14 EP disclosed
EP-1752191-A1 Agent for bleaching and/or colouring keratinic fibres with a coated alkaline agent Henkel Kommanditgesellschaft auf Aktien (DE) 2007-02-14 EP disclosed
WO-2007009530-A1 HAIR-TREATMENT KIT COMPRISING A DYE AND AN ADHESIVE STRIP AS A DYE-PROTECTION MEANS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-01-25 WO disclosed
WO-2007006418-A1 IONIC-LIQUID-CONTAINING PRODUCTS FOR DYEING AND/OR BRIGHTENING KERATIN FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-01-18 WO disclosed