Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1452243 | 0.80 | TRPV1 (0.42) | TRPV1 | |
| SCHEMBL2733666 | 0.74 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL5677912 | 0.74 | BCL2L1 (0.46) | HTR2AHTR2CHTR2B | |
| SCHEMBL2733639 | 0.74 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL2734503 | 0.74 | TRPV1 (0.49) | TRPV1 | |
| SCHEMBL4813078 | 0.72 | CHRM3 (0.65) | HTR2AHTR2CHTR2B | |
| SCHEMBL6905933 | 0.72 | HTR2A (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL23045126 | 0.70 | DRD2 (0.50) | TRPV1 | |
| SCHEMBL23045121 | 0.70 | TRPV1 (0.45) | TRPV1 | |
| SCHEMBL23045125 | 0.70 | CHRM3 (0.42) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102272081-B | Tetrahydronaphthalen-2-ol derivatives | MERCK SHARP & DOHME | 2014-04-30 | — | — | CN | disclosed |
| EP-2406206-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | MSD Oss B.V. (NL) | 2012-01-18 | — | — | EP | disclosed |
| CN-102272081-A | Tetrahydronaphthalen-2-ol derivatives | — | 2011-12-07 | — | — | CN | disclosed |
| WO-2010103095-A1 | TETRAHYDRONAPHTHALEN-2-OL DERIVATIVES | N.V. ORGANON (NL) | 2010-09-16 | — | — | WO | disclosed |