SCHEMBL172489

SCHEMBL172489

O=COc1ccc(Nc2ccc(OC=O)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.48
MAPK1 P28482 4/20 0.48
TDP1 Q9NUW8 4/20 0.48
RAB9A P51151 4/20 0.48
GAA P10253 3/20 0.48
L3MBTL1 Q9Y468 3/20 0.48
KDM4E B2RXH2 2/20 0.48
NPC1 O15118 2/20 0.48
THRB P10828 1/20 0.48
RECQL P46063 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
NR4A1 P22736 1/20 0.40
ALDH1A1 P00352 8/20 0.39
HSP90AA1 P07900 1/20 0.39
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
PTPN7 P35236 1/20 0.38
PTPN12 Q05209 1/20 0.38
HSD17B10 Q99714 5/20 0.38
TSHR P16473 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12218044 0.88 RAD52 (0.48) MAPTMAPK1TDP1RAB9AGAA
SCHEMBL6454577 0.84 ALDH1A1 (0.38) KDM4EALDH1A1SMN1; SMN2LMNA
SCHEMBL12881975 0.81 APP (0.40) MAPTGAATHRBRECQLALDH1A1
SCHEMBL7295754 0.81 ALDH1A1 (0.50) MAPTMAPK1TDP1RAB9AGAA
SCHEMBL18683261 0.81 ALDH1A1 (0.41) MAPTMAPK1TDP1RAB9AGAA
SCHEMBL69853 0.81 CA2 (0.40) MAPTMAPK1TDP1RAB9AGAA
SCHEMBL13095588 0.79 ALDH1A1 (0.45) MAPTMAPK1TDP1RAB9AGAA
SCHEMBL10465750 0.78 ALDH1A1 (0.32) RAB9AGAANPC1ALDH1A1HPGD
SCHEMBL10466115 0.78
SCHEMBL28652357 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1847881-B1 Image forming apparatus, image forming method, and process cartridge RICOH CO LTD (JP) 2012-03-07 EP disclosed