Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9988990 | 0.69 | IDH1 (0.39) | — | |
| SCHEMBL34470588 | 0.67 | CNR2 (0.38) | — | |
| SCHEMBL28191634 | 0.60 | HCAR2 (0.52) | PTGS2 | |
| SCHEMBL29955798 | 0.60 | HCAR2 (0.52) | PTGS2 | |
| SCHEMBL9316209 | 0.58 | PARP1 (0.42) | PTGS2PARP1 | |
| SCHEMBL6774970 | 0.57 | NAPRT (0.44) | PTGS1PTGS2PARP1 | |
| SCHEMBL6551393 | 0.57 | HDAC8 (0.46) | PTGS2PARP1 | |
| SCHEMBL28500105 | 0.57 | HTT (0.49) | — | |
| SCHEMBL20876169 | 0.56 | ALOX15 (0.54) | PARP1 | |
| SCHEMBL30108195 | 0.56 | RAF1 (0.53) | PTGS2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406233-A1 | AZA PYRIDONE ANALOGS USEFUL AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104818-A1 | AZA PYRIDONE ANALOGS USEFUL AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-09-16 | — | — | WO | disclosed |