Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30991234 | 0.98 | ALDH1A1 (0.41) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| Hydrochloric Acid SCHEMBL8404079 | 0.84 | KMT2A (0.46) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| Hydrochloric Acid SCHEMBL8404082 | 0.84 | KMT2A (0.46) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| SCHEMBL14647878 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1SMN1; SMN2CA12 | |
| SCHEMBL12710386 | 0.84 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1SMN1; SMN2CA12 | |
| SCHEMBL23450303 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| SCHEMBL23450556 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| SCHEMBL31261530 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| SCHEMBL5548453 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPTNPSR1NPC1NFKB1 | |
| SCHEMBL17254235 | 0.76 | KDM4E (0.46) | ALDH1A1MAPTNPSR1NPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3655408-B1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | US HEALTH (US) | 2021-07-14 | — | — | EP | claimed |
| US-10994029-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-05-04 | — | — | US | claimed |
| US-20200179536-A1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2020-06-11 | — | — | US | claimed |
| US-11707537-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-07-25 | — | — | US | disclosed |
| US-20210220490-A1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2021-07-22 | — | — | US | disclosed |
| EP-3655408-B1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | US HEALTH (US) | 2021-07-14 | — | — | EP | disclosed |
| US-10994029-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-05-04 | — | — | US | disclosed |
| EP-3476830-B1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LTD (GB) | 2021-01-13 | — | — | EP | disclosed |
| US-20200179536-A1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2020-06-11 | — | — | US | disclosed |
| US-20160177388-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2016-06-23 | — | — | US | disclosed |
| US-9309409-B2 | Polymethine compounds and their use as fluorescent labels | ILLUMINA CAMBRIDGE LIMITED (GB) | 2016-04-12 | — | — | US | disclosed |
| US-20150322266-A1 | POLYMETHINE COMPOUNDS AND THEIR USE AS FLUORESCENT LABELS | ILLUMINA CAMBRIDGE LIMITED (GB) | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210220490-A1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | IK, FAR1, SPR | ALDH1A1 629/4885MAPT 1306/4885NPSR1 315/4885 |
| US-10994029-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | IK, FAR1, SPR | ALDH1A1 629/4885MAPT 1306/4885NPSR1 315/4885 |
| US-20200179536-A1 | CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN FAR-RED AND NEAR-IR RANGE | IK, FAR1, SPR | ALDH1A1 629/4885MAPT 1306/4885NPSR1 315/4885 |
| US-11707537-B2 | Conformational restriction of cyanine fluorophores in far-red and near-IR range | IK, FAR1, SPR | ALDH1A1 629/4885MAPT 1306/4885NPSR1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.