Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20627544 | 0.88 | PARP11 (0.61) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL10168733 | 0.80 | PARP11 (0.66) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL25947316 | 0.80 | PARP11 (0.66) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL8190887 | 0.77 | PARP10 (0.58) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL19386434 | 0.77 | PARP11 (0.61) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL14678288 | 0.75 | PARP11 (0.56) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL279822 | 0.74 | PARP10 (0.63) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL19454258 | 0.74 | PARP11 (1.00) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL8269655 | 0.73 | PARP11 (0.47) | PARP11PARP10PARP1PDPK1GRM5 | |
| SCHEMBL12194628 | 0.73 | DAPK3 (0.46) | PARP11PARP10GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403846-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100070-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |