Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | STK3 | Q13188 | 1/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726008 | 0.83 | ROCK2 (0.63) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL882717 | 0.83 | ROCK2 (0.69) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL13154697 | 0.83 | TGFBR1 (0.71) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL29395013 | 0.83 | TGFBR1 (0.71) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL3789051 | 0.82 | ROCK2 (0.68) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL3587569 | 0.81 | TGFBR1 (0.69) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL1727391 | 0.80 | ROCK2 (0.74) | ROCK2ROCK1AURKBCLK2DYRK1A | |
| SCHEMBL26389170 | 0.80 | ROCK2 (0.70) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL31484231 | 0.80 | ROCK2 (0.70) | ROCK2TGFBR1ROCK1AURKBCLK2 | |
| SCHEMBL3590236 | 0.80 | ROCK2 (0.78) | ROCK2TGFBR1ROCK1AURKBCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | claimed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | claimed |
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |