Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 6/20 | 0.46 |
| ▸ | BACE1 | P56817 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725311 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL611817 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL611818 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL611816 | 1.00 | DRD2 (0.51) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL1725367 | 0.92 | DRD2 (0.49) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL149641 | 0.92 | DRD2 (0.49) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL1725370 | 0.92 | DRD2 (0.49) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL121059 | 0.92 | DRD2 (0.49) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL149642 | 0.92 | DRD2 (0.49) | DRD2DRD3DPP4ACHEBACE1 | |
| SCHEMBL13186505 | 0.91 | ACHE (0.52) | DRD2DRD3DPP4ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406256-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103335-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |