Citric Acid

Citric Acid

SCHEMBL1725324

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(O)O.[NaH]

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.37
ALDH1A1 P00352 3/20 0.75
HMGCR P04035 1/20 0.40
CHRM1 P11229 1/20 0.40
TBXA2R P21731 1/20 0.40
ADRA1A P35348 1/20 0.40
TSHR P16473 2/20 0.39
CYP2D6 P10635 2/20 0.39
KDM4E B2RXH2 2/20 0.39
LMNA P02545 2/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
ACLY P53396 4/20 0.38
SLC13A5 Q86YT5 4/20 0.38
CPT2 P23786 1/20 0.37
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL28028993 1.00 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL11060467 1.00 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL8501344 1.00 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10947826 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28098594 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1470535 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3825579 0.97 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28204445 0.95 ALDH1A1 (0.68) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7563521 0.95 ALDH1A1 (0.68) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL347802 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9931362-B2 Composition for controlling fish Gregg, Kenneth William (US) 2018-04-03 US claimed
US-20150265659-A1 COMPOSITION FOR CONTROLLING FISH GREGG KENNETH WILLIAM (US) 2015-09-24 US claimed
EP-2403353-A2 COMPOSITION FOR CONTROLLING FISH Gregg, Kenneth William (US) 2012-01-11 EP claimed
WO-2010102202-A2 COMPOSITION FOR CONTROLLING FISH GREGG KENNETH WILLIAM (US) 2010-09-10 WO claimed
US-20100226876-A1 COMPOSITION FOR CONTROLLING FISH GREGG KENNETH WILLIAM 2010-09-09 US claimed
EP-1021501-A4 CATIONIC DETERGENT COMPOUNDS PROCTER & GAMBLE (US) 2004-05-06 EP disclosed
EP-0934377-A4 DETERGENT COMPOSITIONS PROCTER & GAMBLE (US) 2001-02-07 EP disclosed
EP-0934389-A4 DETERGENT COMPOSITIONS PROCTER & GAMBLE (US) 2001-02-07 EP disclosed
EP-1021501-A1 CATIONIC DETERGENT COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 2000-07-26 EP disclosed
EP-0934397-A4 DETERGENT COMPOSITIONS PROCTER & GAMBLE (US) 2000-02-23 EP disclosed
EP-0973855-A1 BLEACH COMPOSITIONS CONTAINING METAL BLEACH CATALYST, AND BLEACH ACTIVATORS AND/OR ORGANIC PERCARBOXYLIC ACIDS THE PROCTER & GAMBLE COMPANY (US) 2000-01-26 EP disclosed
EP-0970169-A4 DETERGENT COMPOSITIONS COMPRISING A MIXTURE OF QUATERNARY AMMONIUM CATIONIC SURFACTANT AND ALKYL SULFATE ANIONIC SURFACTANT PROCTER & GAMBLE (US) 2000-01-12 EP disclosed
WO-1998017777-A1 DETERGENT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 1998-04-30 WO disclosed
WO-1998017759-A1 DETERGENT COMPOSITIONS COMPRISING A MIXTURE OF QUATERNARY AMMONIUM CATIONIC SURFACTANT AND ALKYL SULFATE ANIONIC SURFACTANT THE PROCTER & GAMBLE COMPANY (US) 1998-04-30 WO disclosed
WO-1998000489-A1 DETERGENT COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 1998-01-08 WO disclosed
WO-1997043371-A2 DETERGENT COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 1997-11-20 WO disclosed
WO-1997043364-A2 DETERGENT COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 1997-11-20 WO disclosed
WO-1997032955-A1 CATIONIC DETERGENT COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 1997-09-12 WO disclosed
WO-1997032956-A1 DETERGENT COMPONENT COMPRISING METAL ION-CONTAINING CRYSTALLINE LAYERED SILICATE THE PROCTER & GAMBLE COMPANY (US) 1997-09-12 WO disclosed
US-4681976-A Process for preparing alkyl substituted and unsubstituted para-carboalkoxy cyclohexanones INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1987-07-21 US disclosed