Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 4/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8634729 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3825579 | 0.97 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28591636 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6571073 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL19926506 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11060467 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8501344 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5464340 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20537178 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7047617 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210127710-A1 | Domestic Animal Water and Feed Modifying Compositions | ITI TECHNOLOGIES, INC. (US) | 2021-05-06 | — | — | US | claimed |
| US-10940228-B2 | Aqueous solutions of copper salts and hydrogen peroxide | 2PURE PRODUCTS LIMITED (GB) | 2021-03-09 | — | — | US | disclosed |
| EP-2396042-B1 | COMPOSITIONS AND THEIR USE | PROBE INDUSTRIES LTD (GB) | 2018-09-12 | — | — | EP | disclosed |
| US-20180126027-A1 | COMPOSITIONS AND THEIR USES | 2PURE PRODUCTS LIMITED (GB) | 2018-05-10 | — | — | US | disclosed |
| US-9700646-B2 | Compositions and their use | PROBE INDUSTRIES LIMITED (GB) | 2017-07-11 | — | — | US | disclosed |
| US-20140356312-A1 | COMPOSITIONS AND THEIR USE | 2PURE PRODUCTS LIMITED (GB) | 2014-12-04 | — | — | US | disclosed |
| US-8834939-B2 | Aqueous compositions of copper salts and hydrogen peroxide | PROBE INDUSTRIES LIMITED (GB) | 2014-09-16 | — | — | US | disclosed |
| US-20120014902-A1 | COMPOSITIONS AND THEIR USE | PROBE INDUSTRIES LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| EP-2396042-A1 | COMPOSITIONS AND THEIR USE | Probe Industries Limited (GB) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091884-A1 | COMPOSITIONS AND THEIR USE | PROBE INDUSTRIES LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |