Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 14/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17254039 | 0.90 | DHODH (0.62) | DHODHNPSR1NPC1NFKB1RAB9A | |
| SCHEMBL247329 | 0.87 | DHODH (1.00) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL248244 | 0.82 | DHODH (0.71) | DHODHNPSR1MRGPRX4 | |
| SCHEMBL247030 | 0.82 | DHODH (0.77) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL290914 | 0.81 | DHODH (0.89) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18418380 | 0.80 | DHODH (0.73) | DHODHNPSR1NPC1RAB9APARP1 | |
| SCHEMBL247876 | 0.80 | DHODH (0.65) | DHODHNPSR1MRGPRX4 | |
| SCHEMBL3918407 | 0.79 | DHODH (0.71) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL517712 | 0.76 | DHODH (0.85) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3915847 | 0.75 | DHODH (0.78) | DHODHNPSR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015169944-A1 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | PANOPTES PHARMA GES.M.B.H. (AT) | 2015-11-12 | — | — | WO | disclosed |