Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 7/20 | 0.40 |
| ▸ | TDP2 | O95551 | 6/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MPI | P34949 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16476446 | 0.99 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL15908041 | 0.90 | MEN1 (0.43) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL15908087 | 0.85 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL15908096 | 0.84 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL27033894 | 0.83 | KDM4E (0.48) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| Bromide SCHEMBL15901676 | 0.83 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL19415772 | 0.81 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD | |
| SCHEMBL16476439 | 0.80 | KDM4E (0.42) | KDM4EMAPTHTTMEN1USP2 | |
| Bromide SCHEMBL17254518 | 0.79 | KDM4E (0.42) | KDM4EMAPTHTTMEN1USP2 | |
| SCHEMBL14399199 | 0.79 | SMN1; SMN2 (0.58) | KDM4ESMN1; SMN2ALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3586632-B1 | 10H-BENZO[G]PTERIDINE-2,4-DIONE DERIVATIVES, METHOD FOR PRODUCING SAME AND USE OF SAME | TRIOPTOTEC GMBH (DE) | 2022-09-28 | — | — | EP | disclosed |
| US-9185913-B2 | 10H-benzo[g]pteridine-2,4-dione derivatives, method for the production thereof, and use thereof | TRIOPTOTEC GMBH (DE) | 2015-11-17 | — | — | US | disclosed |