Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805891 | 1.00 | BACE1 (0.42) | BACE1USP30PDE4BTLR2TLR1 | |
| SCHEMBL148386 | 1.00 | BACE1 (0.42) | BACE1USP30PDE4BTLR2TLR1 | |
| SCHEMBL148387 | 1.00 | BACE1 (0.42) | BACE1USP30PDE4BTLR2TLR1 | |
| SCHEMBL148055 | 1.00 | BACE1 (0.42) | BACE1USP30PDE4BTLR2TLR1 | |
| SCHEMBL13186500 | 0.88 | PDE4B (0.37) | BACE1USP30PDE4BTLR2TLR1 | |
| SCHEMBL1721964 | 0.86 | KMT2A (0.43) | TLR2TLR1KMT2AF10EPHX2 | |
| SCHEMBL21319696 | 0.86 | BACE1 (0.46) | BACE1USP30TLR2TLR1KMT2A | |
| SCHEMBL12164667 | 0.85 | BACE1 (0.44) | BACE1USP30TLR2TLR1KMT2A | |
| SCHEMBL742949 | 0.84 | BACE1 (0.46) | BACE1USP30TLR2TLR1KMT2A | |
| SCHEMBL6344562 | 0.84 | BACE1 (0.46) | BACE1USP30TLR2TLR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406256-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |