Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17266042 | 0.91 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| Hydrochloric Acid SCHEMBL17257662 | 0.89 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| Hydrochloric Acid SCHEMBL17257613 | 0.83 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL17266008 | 0.80 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3630734 | 0.80 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5008037 | 0.80 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL5004798 | 0.80 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| SCHEMBL3632045 | 0.80 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1HSP90B1TRAP1OPRM1 | |
| Hydrochloric Acid SCHEMBL17257653 | 0.77 | HSP90AB1 (0.66) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| Hydrochloric Acid SCHEMBL17257654 | 0.77 | HSP90AB1 (0.66) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150329493-A1 | OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS | HALL STEVEN E (US) | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329493-A1 | OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS | LTB4R, LTB4R2, PTGER4 | HSP90AB1 3629/4885HSP90AA1 3559/4885HSP90B1 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.