Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 19/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064464 | 0.79 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL798904 | 0.78 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064585 | 0.78 | ADORA2B (0.43) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL797623 | 0.78 | ADORA2B (0.42) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15642929 | 0.75 | ADORA2B (0.52) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL15642922 | 0.75 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064644 | 0.74 | ADORA2B (0.40) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL1725997 | 0.73 | ADORA2B (0.41) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL1725999 | 0.73 | ADORA2B (0.62) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL15064900 | 0.73 | ADORA2B (0.37) | ADORA2BADORA2AADORA1ADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |