Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065022 | 0.87 | PNMT (0.49) | PNMTSLC6A4SLC6A2HTR2AHTR2B | |
| SCHEMBL18255649 | 0.87 | PNMT (0.49) | PNMTSLC6A4SLC6A2HTR2AHTR2B | |
| SCHEMBL11407610 | 0.83 | PNMT (0.47) | PNMTSLC6A4SLC6A2HTR2AHTR2B | |
| SCHEMBL10217243 | 0.83 | PNMT (0.51) | PNMTSLC6A4SLC6A2ALDH1A1POLB | |
| SCHEMBL14262202 | 0.83 | PNMT (0.51) | PNMTSLC6A4SLC6A2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL19244848 | 0.81 | PNMT (0.50) | PNMTSLC6A4SLC6A2EPHX1ALDH1A1 | |
| SCHEMBL23892009 | 0.80 | PDE2A (0.41) | SLC6A4SLC6A2HTR2AHTR2BSIGMAR1 | |
| SCHEMBL19541914 | 0.80 | PNMT (0.51) | TAS1R3TAS1R1PNMTSLC6A4EPHX1 | |
| SCHEMBL18593504 | 0.80 | PNMT (0.45) | PNMTSLC6A4SLC6A2HTR2AHTR2B | |
| SCHEMBL7929105 | 0.79 | PNMT (0.50) | TAS1R3TAS1R1PNMTSLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |