Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286104 | 0.85 | PDE2A (0.43) | PDE2AUTS2RMEN1KMT2ALMNA | |
| SCHEMBL3595285 | 0.84 | UTS2R (0.42) | PDE2AUTS2RMEN1KMT2ASLC6A4 | |
| SCHEMBL172624 | 0.80 | TAS1R3 (0.48) | MEN1KMT2ALMNASLC6A4CYP3A4 | |
| SCHEMBL11625671 | 0.80 | TAAR1 (0.41) | PDE2AUTS2RMEN1KMT2ALMNA | |
| SCHEMBL31137199 | 0.77 | PDE2A (0.39) | PDE2AUTS2RMEN1KMT2ALMNA | |
| SCHEMBL16976289 | 0.77 | PDE2A (0.46) | PDE2AMEN1KMT2ALMNASLC6A4 | |
| SCHEMBL27634082 | 0.76 | UTS2R (0.40) | PDE2AUTS2RMEN1KMT2ALMNA | |
| SCHEMBL2090318 | 0.76 | PDE2A (0.49) | PDE2ALMNASLC6A4CYP3A4CYP2D6 | |
| SCHEMBL24528911 | 0.76 | KMT2A (0.39) | MEN1KMT2ASLC6A4CYP3A4CYP2D6 | |
| SCHEMBL9187166 | 0.76 | PDE2A (0.44) | PDE2AMEN1KMT2ASLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177611-B1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION AS (DK) | 2021-10-06 | — | — | EP | disclosed |