Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680241 | 0.91 | KDM4E (0.48) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL13671319 | 0.90 | KDM4E (0.50) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL1726691 | 0.89 | KDM4E (0.46) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL1421111 | 0.87 | KDM4E (0.47) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL1462885 | 0.84 | MAPT (0.46) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL30625181 | 0.83 | MEN1 (0.47) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL26602491 | 0.83 | MEN1 (0.47) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL1463180 | 0.82 | KDM4E (0.45) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL1462909 | 0.81 | KDM4E (0.48) | KDM4EMAPTTHRBMEN1KMT2A | |
| SCHEMBL2681920 | 0.81 | MEN1 (0.48) | KDM4EMAPTTHRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-07 | — | — | US | disclosed |
| US-9808006-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-11-07 | — | — | US | disclosed |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-28 | — | — | US | disclosed |
| US-8518971-B2 | Insecticidal phenyl- or pyridyl-piperdine compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2012037282-A3 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| EP-2324010-B1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2324010-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | Syngenta Participations AG (CH) | 2011-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | ACHE, CHRM1, CHRM2 | KDM4E 1032/4885MAPT 3218/4885THRB 3436/4885 |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | KDM4E 1032/4885MAPT 3218/4885THRB 3436/4885 |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | KDM4E 1079/4885MAPT 3185/4885THRB 3656/4885 |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | KDM4E 1032/4885MAPT 3218/4885THRB 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.