Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171048 | 0.83 | TP53 (0.48) | TSHRPTGS1EGFRABL1ABL2 | |
| SCHEMBL11023703 | 0.82 | LCK (0.58) | TSHRCASP1PTGS1EGFRABL1 | |
| SCHEMBL23310856 | 0.76 | EGFR (0.44) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL29956905 | 0.76 | KDM4E (0.64) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL29505021 | 0.76 | TRPA1 (0.52) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL11856367 | 0.76 | TSHR (0.46) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL111227 | 0.76 | KDM4E (0.64) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL196749 | 0.76 | TRPA1 (0.52) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL27791652 | 0.75 | PTGS1 (0.47) | TSHRCASP1PTGS1ACHETRPA1 | |
| SCHEMBL13344899 | 0.74 | CNR2 (0.61) | TSHRCASP1PTGS1ACHETRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47302-E1 | Peptide epoxyketone immunoproteasome inhibitors | ONYX THERAPEUTICS INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-9185909-B2 | Synthesis of resveratrol-based natural products | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |