Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59040 | 0.78 | LPL (0.37) | — | |
| SCHEMBL29385065 | 0.78 | LPL (0.37) | — | |
| SCHEMBL2934443 | 0.78 | PIK3R1 (0.38) | — | |
| SCHEMBL23751788 | 0.73 | CA1 (0.33) | CA12CA1CA2CA4CA6 | |
| SCHEMBL15289502 | 0.71 | LPL (0.37) | — | |
| SCHEMBL19668082 | 0.69 | LPL (0.38) | CA12CA1CA2CA4CA6 | |
| SCHEMBL22397836 | 0.68 | EGFR (0.35) | CA12CA1CA2CA4CA6 | |
| SCHEMBL10278788 | 0.68 | — | — | |
| SCHEMBL26674620 | 0.66 | LPL (0.38) | CA12CA1CA2CA4CA6 | |
| SCHEMBL58364 | 0.66 | LPL (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406258-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Cellzome Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103094-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |