Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.30 |
| ▸ | FEN1 | P39748 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814938 | 0.80 | LPL (0.34) | — | |
| SCHEMBL1726378 | 0.78 | CA12 (0.31) | — | |
| SCHEMBL10328173 | 0.70 | — | — | |
| SCHEMBL16055897 | 0.66 | MAP3K12 (0.36) | PIK3R1PIK3CAPIK3CDPIK3CBMTOR | |
| SCHEMBL21828795 | 0.66 | ABL1 (0.35) | PIK3CAMTOR | |
| SCHEMBL22397836 | 0.65 | EGFR (0.35) | — | |
| SCHEMBL13016581 | 0.64 | NOS3 (0.35) | — | |
| SCHEMBL30736300 | 0.63 | NOS3 (0.47) | PIK3R1PIK3CAMTOR | |
| SCHEMBL13089602 | 0.63 | NOS3 (0.47) | PIK3R1PIK3CAMTOR | |
| SCHEMBL20519666 | 0.63 | NOS3 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984350-B1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-08-18 | — | — | EP | disclosed |