Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 13/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 13/20 | 0.55 |
| ▸ | NPC1 | O15118 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11902893 | 0.84 | SMN1; SMN2 (0.56) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11903011 | 0.83 | SMN1; SMN2 (0.72) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL17264636 | 0.83 | SMURF2 (0.57) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12076503 | 0.82 | RAB9A (0.47) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL17264640 | 0.81 | S1PR1 (0.57) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL17264300 | 0.81 | SMN1; SMN2 (0.60) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12076543 | 0.81 | RAB9A (0.46) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL17261642 | 0.80 | SMURF2 (0.59) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11902861 | 0.80 | RAB9A (0.64) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11965065 | 0.80 | CYP1A2 (0.52) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | NOVARTIS AG (CH) | 2017-03-30 | — | — | US | disclosed |
| WO-2015173659-A2 | CARBOXAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2015-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088546-A1 | CARBOXAMIDE INHIBITORS | SMURF1, SMURF2, SMYD2 | MAPT 4004/4885RAB9A 3822/4885SMN1; SMN2 1490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.