Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 8/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896880 | 0.87 | MAP4K4 (0.44) | POLBMEN1KMT2AALDH1A1HTT | |
| SCHEMBL13995707 | 0.83 | DNM1 (0.33) | POLBMEN1KMT2AALDH1A1DNM1 | |
| SCHEMBL18932620 | 0.81 | ALDH1A1 (0.38) | POLBALDH1A1 | |
| SCHEMBL14492262 | 0.80 | DNM1 (0.52) | ALDH1A1CA2MAP4K4HPGDDNM1 | |
| SCHEMBL12659603 | 0.78 | CHRM2 (0.53) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13041031 | 0.77 | MAP4K4 (0.48) | POLBMEN1KMT2AALDH1A1HTT | |
| SCHEMBL183773 | 0.77 | POLB (0.48) | POLBMEN1KMT2AALDH1A1HTT | |
| SCHEMBL8433070 | 0.77 | CHRM2 (0.45) | MEN1KMT2AALDH1A1CA2 | |
| SCHEMBL5595540 | 0.75 | ALDH1A1 (0.35) | POLBMEN1KMT2AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL8433082 | 0.75 | CHRM2 (0.43) | MEN1KMT2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |